Chrome is deprecating the support of its legacy U2F APIs (which are used by the Hardware tokens) in February 2022. So all the apps need to migrate to WebAuthn APIs.
In the recent chrome version, Chrome has disabled the U2F support by default. So if you are using Chrome then you must be getting a warning message on the Chrome browser as below whenever you try to login to your Jira or Confluence account and use Yubikey Hardware Token(U2F).
After February 2022, you will not be able to use U2F APIs. To avoid that, please configure your Hardware token again. This will be a one time process.
Please check the steps given in the section below to find out how you can reconfigure the Hardware token/Security Key.